Canguven Onder, Burnett Arthur
James Buchanan Brady Urological Institute, The Johns Hopkins Hospital-Urology, Baltimore, MD 21287-2411, USA.
J Sex Med. 2008 Aug;5(8):1776-85. doi: 10.1111/j.1743-6109.2008.00955.x.
With the advance of the "nerve sparing" technique in radical pelvic surgeries, medically unaided rates of normal erectile function following surgery have improved. Precise determinations of post-surgery erection recovery, however, continue to be problematic and rates of normal erectile function range from 9% to 86%. It is understood that injury to cavernous nerves (CNs) occurs despite modern modifications of the surgery, although the precise pathophysiologic mechanisms of surgical erectile dysfunction are not completely understood.
To describe the experimental models of CN injury in small rodents, including both survival surgery (CN injury) and non-survival surgery (monitoring of intracavernosal pressure and arterial blood pressure) models. We also summarize studies on experimental procedures relating to these CN injury models and critique techniques according to their advantages and disadvantages.
Data from a peer review literature search on the topic of CN injury in rodent models. Methods. A comprehensive review of the literature was performed using PubMed. "Cavernous nerve injury" and "animal model" were used as search terms, and a manual bibliographic review of cross-referenced items was performed.
Assorted molecular, morphological, and physiological changes are measurable after CN injury in rodent models.
Various models of CN injury have been applied successfully and offer insights regarding erectile function recovery effects.
随着根治性盆腔手术中“保留神经”技术的进步，术后自然勃起功能恢复率有所提高。然而，术后勃起功能恢复的精确判定仍然存在问题，自然勃起功能恢复率在9%至86%之间。据了解，尽管手术方式有了现代改进，但海绵体神经（CNs）仍会受损，不过手术导致勃起功能障碍的确切病理生理机制尚未完全明确。
描述小型啮齿动物海绵体神经损伤的实验模型，包括存活手术（海绵体神经损伤）模型和非存活手术（监测海绵体内压和动脉血压）模型。我们还总结了与这些海绵体神经损伤模型相关的实验程序研究，并根据其优缺点对技术进行了评价。
来自啮齿动物模型中海绵体神经损伤主题的同行评审文献搜索数据。方法。使用PubMed对文献进行全面综述。以“海绵体神经损伤”和“动物模型”作为检索词，并对交叉引用的条目进行手工文献综述。
在啮齿动物模型中，海绵体神经损伤后可测量到各种分子、形态和生理变化。
各种海绵体神经损伤模型已成功应用，并为勃起功能恢复效应提供了见解。
