Rácz Ildikó, Bilkei-Gorzo Andras, Markert Astrid, Stamer Friederike, Göthert Manfred, Zimmer Andreas
Institute of Molecular Psychiatry, Life & Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.
Eur J Pharmacol. 2008 Oct 31;596(1-3):98-101. doi: 10.1016/j.ejphar.2008.08.012. Epub 2008 Aug 24.
Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB(1) and CB(2) receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT(3) receptors as a potential in vivo target for cannabinoids. Mice deficient in CB(1) and CB(2) receptors were treated with Delta(9)-tetrahydrocannabinol and anandamide, in the presence of the 5-HT(3) antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT(3) receptors seem to be involved in cannabinoid analgesia.
对基因敲除小鼠品系的研究表明，一些拟大麻效应在缺乏大麻素CB(1)和CB(2)受体的动物中仍然存在。这些残留效应被认为部分是由大麻素对离子通道的调节作用导致的。本研究调查了5-HT(3)受体作为大麻素潜在体内靶点的作用。在5-HT(3)拮抗剂昂丹司琼存在的情况下，对缺乏CB(1)和CB(2)受体的小鼠给予Δ9-四氢大麻酚和花生四烯乙醇胺进行处理。我们发现，昂丹司琼可完全阻断不依赖大麻素受体的花生四烯乙醇胺镇痛作用，但不能阻断僵住症。因此，5-HT(3)受体似乎参与了大麻素镇痛作用。
