Wu Pingsheng, Dupont William D, Griffin Marie R, Carroll Kecia N, Mitchel Edward F, Gebretsadik Tebeb, Hartert Tina V
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8300, USA.
Am J Respir Crit Care Med. 2008 Dec 1;178(11):1123-9. doi: 10.1164/rccm.200804-579OC. Epub 2008 Sep 5.
Bronchiolitis during infancy is associated with an increased risk of childhood asthma. Whether winter viral infections cause asthma or are a manifestation of a predisposition to asthma development is unknown.
To study the relationship of winter virus infection during infancy and the development of childhood asthma.
We studied over 95,000 infants born between 1995 and 2000 and followed through 2005 who were enrolled in the Tennessee Medicaid program from birth through early childhood to determine whether infant birth in relationship to the winter virus peak alters the risk of developing early childhood asthma.
Among 95,310 children studied during five winter virus seasons from birth through early childhood, the risk of developing asthma tracked with the timing of infant birth in relationship to the winter virus peak. Infant birth approximately 4 months before the winter virus peak carried the highest risk, with a 29% increase in odds of developing asthma compared with birth 12 months before the peak (adjusted odds ratio, 1.29; 95% confidence interval, 1.19-1.40). Infant age at the winter virus peak was comparable to or greater than other known risk factors for asthma.
Timing of birth in relationship to winter virus season confers a differential and definable risk of developing early childhood asthma, establishing winter virus seasonality as a causal factor in asthma development. Delay of exposure or prevention of winter viral infection during early infancy could prevent asthma.
婴儿期细支气管炎与儿童哮喘风险增加相关。冬季病毒感染是导致哮喘还是哮喘易感性的一种表现尚不清楚。
研究婴儿期冬季病毒感染与儿童哮喘发生之间的关系。
我们研究了1995年至2000年出生并在2005年前一直参与田纳西医疗补助计划的95000多名婴儿，这些婴儿从出生到幼儿期都被纳入该计划，以确定与冬季病毒高峰期相关的婴儿出生时间是否会改变患幼儿哮喘的风险。
在从出生到幼儿期的五个冬季病毒流行季节里研究的95310名儿童中，患哮喘的风险与婴儿出生时间相对于冬季病毒高峰期的情况相关。在冬季病毒高峰期前约4个月出生的婴儿患哮喘风险最高，与在高峰期前12个月出生的婴儿相比，患哮喘的几率增加了29%（调整后的优势比为1.29；95%置信区间为1.19 - 1.40）。冬季病毒高峰期时的婴儿年龄与其他已知的哮喘风险因素相当或更高。
与冬季病毒季节相关的出生时间赋予了患幼儿哮喘不同且可确定的风险，确定了冬季病毒季节性是哮喘发展的一个因果因素。在婴儿早期延迟接触或预防冬季病毒感染可预防哮喘。
