Filichev Vyacheslav V, Astakhova Irina V, Malakhov Andrei D, Korshun Vladimir A, Pedersen Erik B
Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
Nucleic Acids Symp Ser (Oxf). 2008(52):347-8. doi: 10.1093/nass/nrn175.
Significant alterations in thermal stability of parallel DNA triplexes and antiparallel duplexes were observed upon changing the attachment of ethynylpyrenes from para to ortho in the structure of phenylmethylglycerol inserted as a bulge into DNA (TINA). Insertions of two ortho-TINAs as a pseudo-pair in the middle of the duplex resulted in formation of an excimer band at 505 nm for both 1- and 4-ethynylpyrene analogues.
当将作为凸起插入DNA（TINA）的苯甲基甘油结构中的乙炔基芘的连接位置从对位变为邻位时，观察到平行DNA三链体和反平行双链体的热稳定性发生了显著变化。在双链体中间插入两个邻位-TINA作为假配对，导致1-乙炔基芘和4-乙炔基芘类似物在505nm处均形成准分子带。
