Rai Diwakar, Yadav Dipti, Balzarini J, De Clercq E, Singh Ramendra K
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Nucleic Acids Symp Ser (Oxf). 2008(52):599-600. doi: 10.1093/nass/nrn303.
A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.
已经合成了多种与脂肪酸、二肽和叶酸的姜黄素生物共轭物，即二 - O - 癸酰基姜黄素（2）、二 - O - 色氨酰苯丙氨酸姜黄素（3）、二 - O - 双 -（γ，γ）叶酰姜黄素（4）、C（4）- 乙基 - O - γ - 叶酰姜黄素（5）和4 - O - 乙基 - O - γ - 叶酰姜黄素（6）。共轭物2 - 6已显示出良好的抗病毒特性，对多种病毒（如HIV、HSV、VSV等）的半数有效浓度（EC50）在0.019 - 0.105微摩尔之间。
