Jessel Soenke, Meier Chris
Organic Chemistry, Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Nucleic Acids Symp Ser (Oxf). 2008(52):615-6. doi: 10.1093/nass/nrn311.
The syntheses of several carbocyclic L-nucleoside analogs starting from enantiomerically pure (1R,2S)-2-benzyloxymethylcyclopent-3-enol are described. The key step is the coupling of a protected nucleobase with different cyclopentane derivatives following a modified Mitsunobu protocol.
描述了从对映体纯的(1R,2S)-2-苄氧基甲基环戊-3-烯醇出发合成几种碳环L-核苷类似物的方法。关键步骤是按照改进的 Mitsunobu 反应流程，将受保护的碱基与不同的环戊烷衍生物进行偶联。
