Yatsu Tomoyuki, Hashimoto Mariko, Hikishima Sadao, Magnowska Lucyna, Bzowska Agnieszka, Yokomatsu Tsutomu
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachiouji, Tokyo 192-0392, Japan.
Nucleic Acids Symp Ser (Oxf). 2008(52):661-2. doi: 10.1093/nass/nrn334.
9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine (DFPP-DG) and its related analogues were designed as multi-substrate analogue inhibitors of purine nucleoside phosphorylase (PNP) on the basis of the X-ray crystallographic data obtained for the binary complex of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine (DFPP-G) with calf spleen PNP. One of these analogues, homo-DFPP-DG was found to be a very potent PNP inhibitor at an intracellular (approximately 1 mM) phosphate concentration.
9-(5',5'-二氟-5'-膦酰戊基)-9-脱氮鸟嘌呤（DFPP-DG）及其相关类似物，是基于9-(5',5'-二氟-5'-膦酰戊基)鸟嘌呤（DFPP-G）与小牛脾脏嘌呤核苷磷酸化酶（PNP）二元复合物的X射线晶体学数据，设计而成的嘌呤核苷磷酸化酶（PNP）多底物类似物抑制剂。其中一种类似物，高同型DFPP-DG，发现在细胞内磷酸盐浓度（约1 mM）下是一种非常有效的PNP抑制剂。
