• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis of new non-nucleosidic ligand building blocks for solid-phase oligonucleotide assembly.

作者信息

Jamil Adnan, Zubin Evgeny M, Stetsenko Dmitry A

机构信息

Division of Chemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.

出版信息

Nucleic Acids Symp Ser (Oxf). 2008(52):719-20. doi: 10.1093/nass/nrn363.

DOI:10.1093/nass/nrn363
PMID:18776582
Abstract

Synthesis of new non-nucleosidic building blocks that incorporate 2,2'-biquinoline is described. Starting from readily available bicinchoninic acid, the corresponding bifunctional monomeric reagents for solid-phase oligonucleotide synthesis, phosphoramidite and H-phosphonate, have been prepared. The compounds developed may be useful for the design of sequence-specific artificial nucleases.

摘要

相似文献

1
Synthesis of new non-nucleosidic ligand building blocks for solid-phase oligonucleotide assembly.
Nucleic Acids Symp Ser (Oxf). 2008(52):719-20. doi: 10.1093/nass/nrn363.
2
'Ethylene-bis[phosphonate] nucleic acids': novel monomeric synthons for the solid-phase synthesis of (P-CH2-CH2-P)-bridged oligonucleotides.“乙烯双膦酸核酸”：用于固相合成（P-CH2-CH2-P）桥连寡核苷酸的新型单体合成子。
Chem Biodivers. 2004 Mar;1(3):402-14. doi: 10.1002/cbdv.200490034.
3
Rapid synthesis of oligodeoxyribonucleotides. V. Further studies in solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.寡聚脱氧核糖核苷酸的快速合成。V. 通过磷酸三酯中间体进行寡聚脱氧核糖核苷酸固相合成的进一步研究。
Nucleic Acids Symp Ser. 1980(7):243-57.
4
Porphyrin substituted phosphoramidites: new building blocks for porphyrin-oligonucleotide syntheses.卟啉取代的亚磷酰胺：卟啉-寡核苷酸合成的新构建模块。
Bioorg Med Chem. 2005 Apr 1;13(7):2413-21. doi: 10.1016/j.bmc.2005.01.045.
5
High-yield solution-phase synthesis of di- and trinucleotide blocks assisted by polymer-supported reagents.聚合物负载试剂辅助的二核苷酸和三核苷酸砌块的高产率溶液相合成
Org Lett. 2005 Aug 4;7(16):3485-8. doi: 10.1021/ol0511777.
6
Synthesis of oligonucleotide building blocks of 2'-deoxyguanosine bearing a C8-arylamine modification.带有C8-芳基胺修饰的2'-脱氧鸟苷寡核苷酸构建块的合成。
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1119-21. doi: 10.1081/NCN-120022751.
7
Solid-phase synthesis of multiantennary oligonucleotide glycoconjugates utilizing on-support oximation.利用载体上的肟化反应进行多臂寡核苷酸糖缀合物的固相合成。
Bioconjug Chem. 2004 Jul-Aug;15(4):890-6. doi: 10.1021/bc049955n.
8
Synthesis of building blocks for solid-phase introduction of diethylenetriaminepentaacetic acid (DTPA) to oligonucleotides and oligopeptides.用于将二乙烯三胺五乙酸（DTPA）固相引入寡核苷酸和寡肽的构建模块的合成。
Bioconjug Chem. 2006 May-Jun;17(3):855-9. doi: 10.1021/bc0503667.
9
Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).寡核苷酸在纤维素上的合成。第二部分：编码胃抑制多肽（GIP）的22个寡脱氧核苷酸的合成设计与合成策略。
Nucleic Acids Symp Ser. 1980(7):225-32.
10
An aminooxy-functionalized non-nucleosidic phosphoramidite for the construction of multiantennary oligonucleotide glycoconjugates on a solid support.
Curr Protoc Nucleic Acid Chem. 2005 Jul;Chapter 4:Unit 4.26. doi: 10.1002/0471142700.nc0426s21.