带有C8-芳基胺修饰的2'-脱氧鸟苷寡核苷酸构建块的合成。
Synthesis of oligonucleotide building blocks of 2'-deoxyguanosine bearing a C8-arylamine modification.
作者信息
Gräsl S, Meier C
机构信息
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1119-21. doi: 10.1081/NCN-120022751.
PMID:14565359
Abstract
C8-Arylamine-dG adducts were synthesized by palladium-catalyzed cross-coupling reactions. The corresponding 5'-O-DMTr-3'-O-phosphoramidite-C8-arylamine-dG adducts were synthesized as potential building blocks for the automated synthesis of site-specifically modified oligonucleotides.
摘要
通过钯催化的交叉偶联反应合成了C8-芳胺-dG加合物。合成了相应的5'-O-二甲氧基三苯甲基-3'-O-亚磷酰胺-C8-芳胺-dG加合物，作为用于自动合成位点特异性修饰寡核苷酸的潜在构件。
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