Propolis suppresses tumor angiogenesis by inducing apoptosis in tube-forming endothelial cells.
作者信息
Ohta Toshiro, Kunimasa Kazuhiro, Kobayashi Tomomi, Sakamoto Miwa, Kaji Kazuhiko
机构信息
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
出版信息
Biosci Biotechnol Biochem. 2008 Sep;72(9):2436-40. doi: 10.1271/bbb.80169. Epub 2008 Sep 7.
PMID:18776674
Abstract
We have reported that propolis suppresses tumor-induced angiogenesis in vivo and in vitro, but antiangiogenic mechanism of propolis at cellular level remains unclear. In this study, we observed that propolis not only inhibited tube formation but also induced apoptosis of endothelial cells. These results suggest that propolis exerts its antiangiogenic effects at least in part through induction of apoptosis.
摘要
Zotero 插件