Elumalai Perumal, Muninathan Natarajan, Megalatha Sadhasivan T, Suresh Arumugam, Kumar Kalimuthu Senthil, Jhansi Nathan, Kalaivani Kuppuswamy, Krishnamoorthy Gunasekaran
Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Central Research Laboratory, Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER University, Enathur, Chennai, Tamil Nadu 631552, India.
Evid Based Complement Alternat Med. 2022 Jun 17;2022:5901191. doi: 10.1155/2022/5901191. eCollection 2022.
Propolis is a natural compound collected by honeybees from different parts of plants. Honeybees produce a sticky component besides honey by mixing the tree resin and other botanical sources with saliva called propolis or bee glue. Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. According to a recent research, natural products are becoming increasingly essential in cancer prevention. Natural products are a great source of potential therapeutic agents, especially in the treatment of cancer. Previous studies have reported that the presence of caffeic acid phenethyl ester (CAPE), artepillin C, and chrysin is responsible for the anticancer potential of propolis. Most of the previous studies suggested that propolis and its active compounds inhibit cancer progression by targeting multiple signaling pathways including phosphoinositide 3-kinases (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signaling molecules, and induce cell cycle arrest. Induction of apoptosis by propolis is mediated through extrinsic and intrinsic apoptotic pathways. The aim of this review is to highlight and summarize the molecular targets and anticancer potential of propolis and its active compounds on cell survival, proliferation, metastasis, and apoptosis in cancer cells.
蜂胶是蜜蜂从植物不同部位采集的一种天然化合物。蜜蜂通过将树脂和其他植物来源与唾液混合，产生了一种除蜂蜜外的粘性成分，即蜂胶或蜂蜡。传统上，蜂胶被用作伤口愈合物质、化妆品、药物以及用于许多其他病症。到目前为止，大多数癌症尚无确切的可治愈疗法，化疗药物和用于靶向治疗的药物都有严重的副作用。根据最近的一项研究，天然产物在癌症预防中变得越来越重要。天然产物是潜在治疗剂的重要来源，尤其是在癌症治疗方面。先前的研究报告称，咖啡酸苯乙酯（CAPE）、artepillin C和白杨素的存在是蜂胶具有抗癌潜力的原因。大多数先前的研究表明，蜂胶及其活性化合物通过靶向多种信号通路，包括磷酸肌醇3激酶（PI3K）/Akt和丝裂原活化蛋白激酶（MAPK）信号分子，来抑制癌症进展，并诱导细胞周期停滞。蜂胶诱导细胞凋亡是通过外源性和内源性凋亡途径介导的。本综述的目的是强调和总结蜂胶及其活性化合物对癌细胞生存、增殖、转移和凋亡的分子靶点及抗癌潜力。
