Matsubayashi Tadashi, Ohro Yoichiro, Yagyuu Tomoihiro, Miyahara Jun
Department of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
J Pediatr Hematol Oncol. 2008 Sep;30(9):701-3. doi: 10.1097/MPH.0b013e318175812c.
A 10-year-old girl presented with T-cell lymphoblastic lymphoma of the mediastinum coexisting with myelodysplastic syndrome. Bone marrow examination showed trilineage dysplasia with no evidence of lymphoma cells. Intensive chemotherapy led to a marked reduction in the mediastinal tumor, but no improvement in bone marrow findings. Unrelated cord blood transplantation was performed, resulting in completely chimeric bone marrow cells. A possible explanation for the simultaneous presentation of T-cell lymphoblastic lymphoma and myelodysplastic syndrome is that transformation occurs in pluripotent stem cells differentiating into myeloid and lymphoid cells.
一名10岁女孩被诊断为纵隔T细胞淋巴母细胞淋巴瘤合并骨髓增生异常综合征。骨髓检查显示三系发育异常，未发现淋巴瘤细胞。强化化疗使纵隔肿瘤明显缩小，但骨髓检查结果无改善。进行了无关脐血移植，导致骨髓细胞完全嵌合。T细胞淋巴母细胞淋巴瘤和骨髓增生异常综合征同时出现的一个可能解释是，在多能干细胞分化为髓系和淋巴系细胞的过程中发生了转化。
