Mozzachiodi Riccardo, Lorenzetti Fred D, Baxter Douglas A, Byrne John H
Department of Neurobiology and Anatomy, W.M. Keck Center for Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, 6431 Fannin Street, Suite MSB 7.046, Houston, Texas 77030, USA.
Nat Neurosci. 2008 Oct;11(10):1146-8. doi: 10.1038/nn.2184. Epub 2008 Sep 7.
Learning can lead to changes in the intrinsic excitability of neurons. However, the extent to which these changes persist and the role they have in the expression of memory remain unclear. We found that in vitro analogs of operant conditioning produced a long-term (24 h) increase in the excitability of an identified neuron (B51) that is critical for the expression of feeding in Aplysia. This increase in excitability, which was cAMP dependent, contributed to the associative modification of the feeding circuitry, providing a mechanism for long-term memory.
学习能够导致神经元内在兴奋性的改变。然而，这些变化持续的程度以及它们在记忆表达中所起的作用仍不清楚。我们发现，操作性条件反射的体外类似物使一种特定神经元（B51）的兴奋性产生了长期（24小时）增加，而该神经元对海兔进食行为的表达至关重要。这种兴奋性的增加依赖于环磷酸腺苷（cAMP），它促成了进食神经回路的关联性修饰，为长期记忆提供了一种机制。
Zotero 插件
