Lin YuChun, Wang JiunJie, Wu CheMing, Wai YauYau, Yu JenFang, Ng ShuHang
Department of Diagnostic Radiology, Chang Gung Memorial Hospital, and Department of Medical Imaging and Radiological Science, Chang Gung University, Taipei, Taiwan.
J Magn Reson Imaging. 2008 Sep;28(3):598-603. doi: 10.1002/jmri.21464.
To prospectively compare diffusion tensor imaging (DTI) measures of axial diffusivity (lambda parallel), radial diffusivity (lambda perpendicular), mean diffusivity (MD), and fractional anisotropy (FA) along the auditory pathway of patients with sensorineural hearing loss (SNHL) and normal controls.
In 37 individuals with SNHL and 10 healthy controls, two regions of interest (ROIs) positioned along the auditory pathway-the lateral lemniscus (LL) and the inferior colliculus (IC)-were investigated bilaterally using diffusion tensor imaging at 3 T. SNHL patients were divided into three groups: patients with bilateral hearing loss, patients with unilateral hearing loss, and patients with partial hearing loss. DTI measures (lambda parallel, lambda perpendicular, MD, FA) of both ROIs were determined in all subjects.
The FA value was reduced and the lambda perpendicular was increased both at the lateral lemniscus and the inferior colliculus of patients with SNHL compared with controls. Similar changes were seen between the ipsilateral and contralateral LL and IC for patients of unilateral profound hearing loss. No changes were observed in any other parameters.
In SNHL patients DTI showed a high radial diffusivity that consequently led to a decreased fractional anisotropy in the LL and the IC.
前瞻性比较感音神经性听力损失（SNHL）患者和正常对照者听觉通路中轴向扩散率（λ∥）、径向扩散率（λ⊥）、平均扩散率（MD）和分数各向异性（FA）的扩散张量成像（DTI）测量值。
对37例SNHL患者和10名健康对照者，在3T条件下使用扩散张量成像对双侧沿听觉通路定位的两个感兴趣区（ROI）——外侧丘系（LL）和下丘（IC）进行研究。SNHL患者分为三组：双侧听力损失患者、单侧听力损失患者和部分听力损失患者。测定所有受试者两个ROI的DTI测量值（λ∥、λ⊥、MD、FA）。
与对照组相比，SNHL患者外侧丘系和下丘的FA值降低，λ⊥升高。单侧重度听力损失患者同侧和对侧的LL和IC之间也观察到类似变化。其他参数未见改变。
在SNHL患者中，DTI显示出较高的径向扩散率，从而导致LL和IC中的分数各向异性降低。
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