Hinshaw V S, Schaffer F L, Chatigny M A
J Natl Cancer Inst. 1976 Oct;57(4):775-8. doi: 10.1093/jnci/57.4.775.
Aerosols of the Moloney murine sarcoma virus (MuSV-M) and leukemia virus (MuLV-M) complex (MuSV-M/MuLV-M) were generated from refluxing atomizers and then aged in rotating drums at 21 degrees C holding temperature with relative humidities ranging from 25 to 76%. The MuSV-M and MuLV-M aerosolized from the same tumor extract preparation survived almost equally at the four humidity levels. Both viruses remained viable in the airborne state for at least 2 hours after aerosolization. When mice were exposed to airborne MuSV-M/MuLV-M, no macroscopic lesions were observed in lungs or other tissues examined during the 2-month postexposure period. On the basis of this study, MuSV-M was determined unsuitable as a "model system" in which a simple aerosol dose response could be used for biohazard evaluation of oncogenic virus aerosols.
莫洛尼氏鼠肉瘤病毒（MuSV-M）和白血病病毒（MuLV-M）复合物（MuSV-M/MuLV-M）的气溶胶由回流雾化器产生，然后在温度为21摄氏度、相对湿度范围为25%至76%的旋转鼓中老化。从同一肿瘤提取物制剂雾化的MuSV-M和MuLV-M在四个湿度水平下的存活情况几乎相同。两种病毒在雾化后至少在空气中存活2小时。当小鼠暴露于空气中的MuSV-M/MuLV-M时，在暴露后2个月的观察期内，在检查的肺部或其他组织中未观察到宏观病变。基于这项研究，MuSV-M被确定不适合作为一种“模型系统”，在该系统中，简单的气溶胶剂量反应可用于致癌病毒气溶胶的生物危害评估。
