Takatsuka Y, Okamura Y, Kawahara T, Yayoi E, Miyauchi K, Shiba E
Dept. of Surgery, Osaka National Hospital.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1682-6.
Long-term follow-up results were reported for 61 patients with locally advanced breast cancer treated by intraarterial infusion chemotherapy (IA), compared with those for 96 patients who received no such treatment. The results were as follows. (1) The response rate of the primary lesions to IA was 53.6%, and the post-surgical survival of responders (CR, PR) was significantly better than those of non-responders (NC). (2) Excellent loco-regional control was also achieved in the IA-group. The local recurrence rate was only 16.2%. (3) However, there was no difference between survival rates of each group. The author confirmed that IA was an effective initial treatment for locally advanced breast cancer in terms of loco-regional control, but definite conclusions can be made only after randomized study.
报告了61例接受动脉内灌注化疗（IA）治疗的局部晚期乳腺癌患者的长期随访结果，并与96例未接受此类治疗的患者进行了比较。结果如下：（1）原发性病变对IA的缓解率为53.6%，缓解者（CR、PR）的术后生存率显著优于未缓解者（NC）。（2）IA组也实现了出色的局部区域控制。局部复发率仅为16.2%。（3）然而，各组的生存率之间没有差异。作者证实，就局部区域控制而言，IA是局部晚期乳腺癌的一种有效初始治疗方法，但只有在进行随机研究后才能得出明确结论。
