Hoshino M, Koyama Y, Abe R
Dept. of Surgery, Fukushima Medical College.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1894-7.
To compare the efficacy of intrahepatic arterial and intraportal venous infusions of anticancer drugs, the following two experiments were performed. 1. Adriamycin (3 mg kg) aqueous solution (ADR) was administered into hepatic artery (HA group) and portal vein (PV group) of a rabbit with 2 cm diameter VX2 liver tumor. The ADR levels of the tumor tended to be about 3-fold higher in HA than in PV group (p less than 0.1) one hour after ADR infusion. No significant difference was seen in the ADR levels of liver, heart, kidney, and bone marrow between the two groups. The ADR concentration ratio of tumor to liver was significantly higher in HA group than in PV group. 2. VX2 tumor cells (1 x 10(7) cells) were transplanted through the portal vein of the rabbit. ADR aqueous solution (1 mg/kg, 5 ml) was infused into the rabbit liver via HA and PV, at 3, 5, and 7 days after tumor inoculation. The rabbits were killed and the livers were excised 21 days after tumor implantation. The number of VX2 tumor nodules on the liver surface was less in HA group than in PV group. These results suggest that hepatic arterial infusion of anticancer drug is more useful to inhibit the growth of liver tumor than portal venous infusion.
为比较肝动脉和门静脉内注射抗癌药物的疗效，进行了以下两项实验。1. 将阿霉素（3毫克/千克）水溶液（ADR）注入患有直径2厘米VX2肝肿瘤的兔子的肝动脉（HA组）和门静脉（PV组）。注射ADR一小时后，HA组肿瘤中的ADR水平往往比PV组高约3倍（p小于0.1）。两组之间肝脏、心脏、肾脏和骨髓中的ADR水平未见显著差异。HA组肿瘤与肝脏的ADR浓度比显著高于PV组。2. 通过门静脉将VX2肿瘤细胞（1×10⁷个细胞）移植到兔子体内。在接种肿瘤后第3、5和7天，通过HA和PV将阿霉素水溶液（1毫克/千克，5毫升）注入兔子肝脏。在肿瘤植入后21天处死兔子并切除肝脏。HA组肝脏表面的VX2肿瘤结节数量比PV组少。这些结果表明，肝动脉内注射抗癌药物比门静脉内注射更有助于抑制肝肿瘤的生长。
