Shirosaki I, Tazawa K, Kushibuchi T, Okamoto M, Yamagishi F, Bandou T, Shimoda M, Takemori S, Suzuki S, Yamashita Y
Second Dept. of Surgery, Toyama Medical and Pharmaceutical University, Faculty of Medicine.
Gan To Kagaku Ryoho. 1993 May;20(7):937-9.
To compare the efficacy of intra-hepatic arterial infusion of anti-cancer drug under temporary occlusion of portal vein, the following two experiments were performed. 1. VX2 tumor cells (about 1 x 10(5) cells) were transplanted through the superior mesenteric vein of the rabbits, after 2 weeks, 4'-0-Tetrahydropyranyl doxorubicin (2 mg/kg, 2 ml) aqueous solution (THP) was administered into hepatic artery of rabbits with metastatic VX2 liver tumor. 2. THP was injected into hepatic artery under temporary occlusion of portal branch of median left lobe with metastatic liver. Then the THP levels of normal liver tissue and tumor of median left lobe and lateral right lobe. The THP levels of tumor under portal occlusion tended to be about 2.63-fold higher than without occlusion. These results suggest that hepatic arterial injection under portal occlusion is more useful to increase the levels of anticancer agents of metastatic liver tumor.
为比较门静脉暂时阻断下肝动脉内注入抗癌药物的疗效，进行了以下两个实验。1. 将VX2肿瘤细胞（约1×10⁵个细胞）经兔肠系膜上静脉移植，2周后，将4'-O-四氢吡喃基阿霉素（2mg/kg，2ml）水溶液（THP）注入患有VX2肝转移瘤的兔肝动脉。2. 在左中叶门静脉分支暂时阻断的情况下，将THP注入患有肝转移的兔肝动脉。然后检测正常肝组织、左中叶肿瘤和右外侧叶肿瘤的THP水平。门静脉阻断下肿瘤的THP水平比未阻断时高出约2.63倍。这些结果表明，门静脉阻断下肝动脉注射更有助于提高肝转移瘤的抗癌药物水平。
