Hasegawa E, Watanabe H, Machida K, Ohmura G, Hirakawa S, Momose K
1st Dept. of Obstetrics and Gynecology, Toho University School of Medicine.
Gan To Kagaku Ryoho. 1991 Aug;18(11):2038-41.
After intraperitoneal administration of cis-diamine-dichloroplatinum, tissue Pt concentration, dynamic CT, and microangiography were estimated in white rabbit model having been transplanted with VX2 ovarian tumor. The high Pt concentration resulting from CDDP intraperitoneal administration was recognized in kidney, liver, and VX2 ovarian tumor. CT scans demonstrated that CDDP administration inhibited the development of VX2 tumor, revealing the appearance of small areas with no enhancement corresponding to necrotic regions in the tumor external rim. A tumor time-density curve showed a significantly delayed washout of the excretory phase following CDDP administration. Regarding microangiography models, tumor vessels of less than 30 microns decreased. It was suggested that the tumor microcirculation diminished because of the increased tissue pressure concomitant with tumor necrosis.
在腹腔注射顺二氯二氨铂后，对移植了VX2卵巢肿瘤的白兔模型进行组织铂浓度、动态CT和微血管造影评估。腹腔注射顺铂后，在肾脏、肝脏和VX2卵巢肿瘤中发现铂浓度升高。CT扫描显示，顺铂给药抑制了VX2肿瘤的生长，肿瘤外缘出现对应坏死区域的无强化小区域。肿瘤时间-密度曲线显示，顺铂给药后排泄期的洗脱明显延迟。关于微血管造影模型，直径小于30微米的肿瘤血管减少。提示肿瘤坏死导致组织压力增加，进而使肿瘤微循环减少。
