Ryuko K, Iwanari O, Moriyama M, Moriyama M, Nakayama S, Miyako J, Kitao M
Dept. of Obstetrics and Gynecology, Shimane Medical University.
Gan To Kagaku Ryoho. 1991 Aug;18(11):2052-7.
A total of 38 cycles of intraperitoneal chemotherapy through implantable injection port were carried out in 9 patients with advanced or recurrent ovarian (tubal) carcinoma. The combination chemotherapy consisted of cisplatin 100 mg or carboplatin 450 mg, 5-FU 500 mg and OK-432 10 KE was administered every four weeks for a total of six cycles. Clinical response was evaluated after chemotherapy. Of the eight evaluated patients (in one patient chemotherapy is not completed yet), 1 had complete response, 3 partial response, 2 stable disease and 2 progressive disease. Therapy-related toxic effects were moderate, consisting chiefly of myelosuppression that seemed dose limiting.
对9例晚期或复发性卵巢（输卵管）癌患者通过植入式注射端口进行了总共38个周期的腹腔内化疗。联合化疗方案为每四周给予顺铂100mg或卡铂450mg、5-氟尿嘧啶500mg和溶链菌制剂10KE，共六个周期。化疗后评估临床反应。在8例接受评估的患者中（1例患者化疗尚未完成），1例完全缓解，3例部分缓解，2例病情稳定，2例病情进展。与治疗相关的毒性作用为中度，主要是骨髓抑制，似乎是剂量限制性的。
