Jern Patric, Coffin John M
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Cell Host Microbe. 2008 Sep 11;4(3):196-7. doi: 10.1016/j.chom.2008.08.008.
In this issue of Cell Host & Microbe, OhAinle et al., 2008 report that APOBEC3H, a potent innate retroviral restriction factor in primates, lost its function twice independently during recent evolution in humans, stressing an ever present trade-off between benefit and cost of protection against pathogens.
在本期《细胞宿主与微生物》杂志中，奥安勒等人于2008年报道，载脂蛋白B mRNA编辑酶催化多肽样蛋白3H（APOBEC3H）是灵长类动物中一种强大的先天性逆转录病毒限制因子，在人类最近的进化过程中两次独立丧失其功能，这凸显了在抵御病原体的保护中益处与代价之间一直存在的权衡。
