Mitchell P, Torda T, Hickie I, Burke C
School of Psychiatry, University of New South Wales, Kensington.
Aust N Z J Psychiatry. 1991 Jun;25(2):255-61. doi: 10.3109/00048679109077742.
Recent reports of reduced seizure duration with ECT under propofol anaesthesia have led to concerns that propofol may diminish the efficacy of this treatment. To investigate the effect of propofol on the response to ECT, we reviewed records of 66 patients with primary depression treated with ECT, 37 of whom had been assessed prospectively with pre- and post-ECT Hamilton and Zung depression severity ratings. Despite demonstrating that the individual seizure duration was significantly reduced with propofol compared to thiopentone we found no evidence of reduced ECT efficacy with propofol. Courses under propofol anaesthesia were on an average two treatments longer than with thiopentone. Although this difference was not statistically significant this may have been due to a type II error. These results suggest that it is premature to abandon the use of this new anaesthetic agent in ECT without controlled prospective outcome studies.
近期有报告称，在丙泊酚麻醉下进行电休克治疗（ECT）时癫痫发作持续时间缩短，这引发了人们对丙泊酚可能降低该治疗效果的担忧。为了研究丙泊酚对ECT反应的影响，我们回顾了66例接受ECT治疗的原发性抑郁症患者的记录，其中37例患者在ECT治疗前后进行了汉密尔顿和zung抑郁严重程度评分的前瞻性评估。尽管与硫喷妥钠相比，丙泊酚使个体癫痫发作持续时间显著缩短，但我们没有发现丙泊酚降低ECT疗效的证据。丙泊酚麻醉下的疗程平均比硫喷妥钠麻醉下的疗程多两次治疗。虽然这种差异没有统计学意义，但这可能是由于II型错误。这些结果表明，在没有对照的前瞻性结果研究的情况下，放弃在ECT中使用这种新型麻醉剂还为时过早。
