Malsch E, Gratz I, Mani S, Backup C, Levy S, Allen E
Department of Anesthesiology, Medical College Hospital, Philadelphia, Pennsylvania.
Convuls Ther. 1994 Sep;10(3):212-9.
Fifty-eight patients with major depression were randomly assigned to receive a hypnotic dose of either propofol or methohexital for their complete treatment series of electroconvulsive therapy (ECT). As expected, seizure duration was significantly shorter with propofol than with methohexital anesthesia. Both groups recovered from their depression at the same rate. There was a significant improvement in the Hamilton Rating Scale for Depression scores between the first and last ECT session. However, this was independent of the choice of propofol or methohexital as the anesthetic. This study supports previous reports that seizure duration does not influence recovery from depression.
58名重度抑郁症患者被随机分配，在整个电休克治疗（ECT）系列疗程中接受催眠剂量的丙泊酚或美索比妥。正如预期的那样，丙泊酚麻醉下的癫痫发作持续时间明显短于美索比妥麻醉。两组患者抑郁症的康复速度相同。在首次ECT治疗和最后一次ECT治疗之间，汉密尔顿抑郁量表评分有显著改善。然而，这与选择丙泊酚还是美索比妥作为麻醉剂无关。这项研究支持了之前的报告，即癫痫发作持续时间不影响抑郁症的康复。
