以物质所致精神病为例，制定并测试适应性治疗策略。
Developing and testing adaptive treatment strategies using substance-induced psychosis as an example.
作者信息
Dawson Ree, Green Alan I, Drake Robert E, McGlashan Thomas H, Schanzer Bella, Lavori Philip W
机构信息
Frontier Science & Technology Research Foundation, Boston, MA, USA.
出版信息
Psychopharmacol Bull. 2008;41(3):51-67.
Abstract
Decisions concerning treatment changes pervade the management of chronic psychiatric disorders that resist definitive cure, yet empirical evidence for the comparative clinical effectiveness of treatment strategies remains underdeveloped. In this paper we exploit the example of psychosis following substance use to illustrate some new developments in clinical trials design that can provide the most solid evidence base for defining successful strategies. The intent is to explore the strengths and limitations of the methodological approach through a meaningful clinical example, with an emphasis on concepts and issues. Both methodology and clinical science are overviewed.
摘要
关于治疗方案变更的决策贯穿于慢性精神疾病的管理过程中，这些疾病难以彻底治愈，然而治疗策略的相对临床疗效的实证证据仍不完善。在本文中，我们以物质使用所致精神病为例，来说明临床试验设计中的一些新进展，这些进展可为确定成功的策略提供最坚实的证据基础。目的是通过一个有意义的临床实例来探讨该方法的优势和局限性，重点关注概念和问题。本文对方法学和临床科学均进行了概述。
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