Khan Arif, Khan Shirin
Northwest Clinical Research Center, Bellevue, WA, USA.
Psychopharmacol Bull. 2008;41(3):91-8.
Practicing clinicians appreciate that depression is not an easy disorder to treat and manage. Despite the plethora of new treatments-both pharmacological and non pharmacological-that has flooded the market in the past years, we are still nowhere close to obtaining full symptom relief for all patients and eradicating the morbidity and mortality associated with depression. In this context, recent methodological research, concentrating on the effectiveness of antidepressants has raised doubts about their therapeutic index. Because of obtuseness of the methodology and biased interpretations, we are submitting this perspective to clinicians so that they can appreciate some of the deficits of the recent research publications. For the practicing clinician, the best available data suggest that clinically depressed patients warrant treatment and the most robust available body of data (published and unpublished) would favor the use of antidepressants.
执业临床医生深知抑郁症并非一种易于治疗和管理的疾病。尽管在过去几年里，大量新的治疗方法——包括药物治疗和非药物治疗——充斥市场，但我们距离让所有患者完全缓解症状、根除与抑郁症相关的发病率和死亡率仍相差甚远。在此背景下，近期专注于抗抑郁药疗效的方法学研究对其治疗指数提出了质疑。由于方法的迟钝和有偏差的解释，我们向临床医生提交此观点，以便他们能认识到近期研究出版物中的一些不足之处。对于执业临床医生而言，现有最佳数据表明临床抑郁症患者需要治疗，而最有力的现有数据（已发表和未发表的）支持使用抗抑郁药。
