Sekar N, Govindasamy S
Department of Biochemistry, University of Madras, India.
Biochem Int. 1991 Feb;23(3):461-6.
Vanadate possesses insulin-mimetic effects, and has been reported to correct the metabolic imbalances in streptozotocin-induced diabetes. Rats were made diabetic by a single i.v. injection of streptozotocin (55 mg/kg body weight) in citrate buffer. After the onset of diabetes, the diabetic rats were treated with sodium orthovanadate (0.3 mg/ml) for 15 days. The increased percentage of 125 I insulin binding to the liver plasma membrane insulin receptors and increased plasma membrane phospholipids were found to be reduced significantly in vanadate treated diabetes. Hence the mode of action of vanadate may be similar to that insulin.
钒酸盐具有胰岛素模拟作用，据报道可纠正链脲佐菌素诱导的糖尿病中的代谢失衡。通过在柠檬酸盐缓冲液中单次静脉注射链脲佐菌素（55毫克/千克体重）使大鼠患糖尿病。糖尿病发病后，用原钒酸钠（0.3毫克/毫升）治疗糖尿病大鼠15天。发现在钒酸盐治疗的糖尿病中，与肝细胞膜胰岛素受体结合的125I胰岛素增加的百分比以及细胞膜磷脂增加的情况均显著降低。因此，钒酸盐的作用方式可能与胰岛素相似。
