Sekar N, Govindasamy S
Department of Biochemistry, University of Madra, India.
Biochem Int. 1991 Mar;23(5):935-40.
The insulin-like effects of vanadate have been intensively studied in the biological system. Lipids and lipoprotein profiles are altered in diabetes. Rats were made diabetic by a single i.v. injection of streptozotocin (55 mg/kg body weight) in citrate buffer. After the overt of diabetes, the diabetic rats were treated with sodium orthovanadate (0.3 mg/ml) for fifteen days. The altered cholesterol, phospholipids and triglycerides in plasma lipoprotein fractions (HDL, LDL and VLDL) were found to be reverted back to near normal levels in vanadate treated diabetic rats.
钒酸盐的胰岛素样作用已在生物系统中得到深入研究。糖尿病患者的脂质和脂蛋白谱会发生改变。通过在柠檬酸盐缓冲液中单次静脉注射链脲佐菌素（55毫克/千克体重）使大鼠患糖尿病。糖尿病症状出现后，给糖尿病大鼠用原钒酸钠（0.3毫克/毫升）治疗15天。结果发现，在经钒酸盐治疗的糖尿病大鼠中，血浆脂蛋白组分（高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白）中改变的胆固醇、磷脂和甘油三酯恢复到接近正常水平。
