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用于医学成像的聚合物纳米结构标记：交联程度、间隔长度和电荷密度的重要性

Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density.

作者信息

Xu Jinqi, Sun Guorong, Rossin Raffaella, Hagooly Aviv, Li Zicheng, Fukukawa Ken-Ichi, Messmore Benjamin W, Moore Dennis A, Welch Michael J, Hawker Craig J, Wooley Karen L

机构信息

Center of Materials Innovation and Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO 63130.

出版信息

Macromolecules. 2007;40(9):2971-2973. doi: 10.1021/ma070267j.

DOI:10.1021/ma070267j
PMID:18779874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2531250/
Abstract

Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.

摘要

采用放射性标记研究来探究结构对两种胺基末端DOTA螯合剂修饰的聚（丙烯酸）包覆的壳交联纳米粒子（SCK）表面功能化效率的影响。研究揭示了DOTA衍生物与SCK纳米结构的化学和物理性质之间复杂的相互作用，证明了结构控制的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd9/2531250/1f152e5bf5d4/nihms62256f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd9/2531250/a14da3026c57/nihms62256f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd9/2531250/1f152e5bf5d4/nihms62256f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd9/2531250/a14da3026c57/nihms62256f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd9/2531250/1f152e5bf5d4/nihms62256f2.jpg

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