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合成聚合物纳米颗粒与来自大肠杆菌菌毛的 FimH(A)缀合，以模拟细菌的上皮内化模式。

Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

机构信息

Department of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.

出版信息

J Am Chem Soc. 2012 Mar 7;134(9):3938-41. doi: 10.1021/ja2091917. Epub 2012 Feb 23.

DOI:10.1021/ja2091917
PMID:22360307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3325780/
Abstract

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

摘要

两亲性嵌段共聚物纳米粒子通过酰胺化学与尿路致病性大肠杆菌 1 型菌毛黏附因子 FimH(A)缀合，以实现纳米粒子在体外与膀胱上皮细胞的结合和内化。

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Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.合成聚合物纳米颗粒与来自大肠杆菌菌毛的 FimH(A)缀合，以模拟细菌的上皮内化模式。
J Am Chem Soc. 2012 Mar 7;134(9):3938-41. doi: 10.1021/ja2091917. Epub 2012 Feb 23.
2
Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.人尿可降低致病性大肠杆菌1型菌毛的功能和表达。
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Exploring the 3D molecular architecture of Escherichia coli type 1 pili.探索大肠杆菌1型菌毛的三维分子结构。
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Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?尿路感染：哪种细菌凝集素 FimH 的构象与治疗相关？
J Med Chem. 2017 Jul 13;60(13):5646-5662. doi: 10.1021/acs.jmedchem.7b00342. Epub 2017 May 11.
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Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.受体结合研究揭示了一类新型的大肠杆菌FimH粘附素高亲和力抑制剂。
Mol Microbiol. 2005 Jan;55(2):441-55. doi: 10.1111/j.1365-2958.2004.04415.x.
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Type 1 fimbrial adhesin FimH elicits an immune response that enhances cell adhesion of Escherichia coli.1 型菌毛黏附素 FimH 引发免疫应答，增强大肠杆菌的细胞黏附。
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Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.肺炎克雷伯菌和大肠杆菌菌毛黏附素（FimH）的分子变异影响尿路中的功能及发病机制。
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Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.基于FimH-低聚甘露糖-3复合物晶体结构，使用抗黏附剂干预尿路感染。
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The shaft of the type 1 fimbriae regulates an external force to match the FimH catch bond.1 型菌毛轴调节外力以匹配 FimH 捕获键。
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Morphologic Design of Silver-Bearing Sugar-Based Polymer Nanoparticles for Uroepithelial Cell Binding and Antimicrobial Delivery.用于尿路上皮细胞结合和抗菌递送的含银糖基聚合物纳米颗粒的形态设计
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Bioadhesive Bacterial Microswimmers for Targeted Drug Delivery in the Urinary and Gastrointestinal Tracts.用于泌尿道和胃肠道靶向给药的生物粘附性细菌微游动器
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本文引用的文献

1
Type 1 fimbrial adhesin FimH elicits an immune response that enhances cell adhesion of Escherichia coli.1 型菌毛黏附素 FimH 引发免疫应答，增强大肠杆菌的细胞黏附。
Infect Immun. 2011 Oct;79(10):3895-904. doi: 10.1128/IAI.05169-11. Epub 2011 Jul 18.
2
The importance of chemistry in creating well-defined nanoscopic embedded therapeutics: devices capable of the dual functions of imaging and therapy.化学在创造明确界定的纳米嵌入治疗中的重要性：能够实现成像和治疗双重功能的设备。
Acc Chem Res. 2011 Oct 18;44(10):969-78. doi: 10.1021/ar200097k. Epub 2011 Jun 15.
3
Tuning core vs. shell dimensions to adjust the performance of nanoscopic containers for the loading and release of doxorubicin.调整纳米容器的核壳尺寸以调节其对阿霉素的装载和释放性能。
J Control Release. 2011 May 30;152(1):37-48. doi: 10.1016/j.jconrel.2011.01.009. Epub 2011 Jan 15.
4
Polymer particle shape independently influences binding and internalization by macrophages.聚合物颗粒的形状会独立影响巨噬细胞的结合和内化。
J Control Release. 2010 Nov 1;147(3):408-12. doi: 10.1016/j.jconrel.2010.07.116. Epub 2010 Aug 5.
5
Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics.载银抗菌剂的壳交联纳米颗粒作为治疗剂。
Chem Commun (Camb). 2010 Jan 7;46(1):121-3. doi: 10.1039/b916559b. Epub 2009 Nov 9.
6
A murine model of urinary tract infection.一种尿路感染的小鼠模型。
Nat Protoc. 2009;4(8):1230-43. doi: 10.1038/nprot.2009.116. Epub 2009 Jul 30.
7
Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density.用于医学成像的聚合物纳米结构标记：交联程度、间隔长度和电荷密度的重要性
Macromolecules. 2007;40(9):2971-2973. doi: 10.1021/ma070267j.
8
Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract.尿路致病性大肠杆菌在泌尿道中持续存在及清除的机制
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14170-5. doi: 10.1073/pnas.0602136103. Epub 2006 Sep 12.
9
Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials.溴化银纳米颗粒/聚合物复合材料：双作用可调谐抗菌材料。
J Am Chem Soc. 2006 Aug 2;128(30):9798-808. doi: 10.1021/ja061442z.
10
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