合成聚合物纳米颗粒与来自大肠杆菌菌毛的 FimH(A)缀合，以模拟细菌的上皮内化模式。
Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.
机构信息
Department of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.
出版信息
J Am Chem Soc. 2012 Mar 7;134(9):3938-41. doi: 10.1021/ja2091917. Epub 2012 Feb 23.
Abstract
Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.
摘要
两亲性嵌段共聚物纳米粒子通过酰胺化学与尿路致病性大肠杆菌 1 型菌毛黏附因子 FimH(A)缀合，以实现纳米粒子在体外与膀胱上皮细胞的结合和内化。
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