Guimarães A R, Costa Rosa L F, Sitnik R H, Curi R
Department of Physiology and Biophysics, São Paulo University, Brazil.
Biochem Int. 1991 Feb;23(3):533-43.
Previous reports of our laboratory have shown that PUFA (n-6)-rich diets cause important changes of the metabolism of the immune tissues. In this study, alterations of macrophage metabolism and function were examined in rats fed polyunsaturated (UC) or saturated (SC) fatty acids-rich diets during 6 weeks. The UC group decreased intraperitoneal cell migration and macrophage phagocytosis. These changes were related to modifications of macrophage metabolism. The UC group showed also increased G-6-PDh in inflammatory macrophages. These findings suggest that pentose-phosphate pathway is not the unique metabolic factor to control phagocytosis. PUFA-rich diet reduced glutaminase activity. Therefore, this amino acid might be one of the possible metabolic reasons for the impaired macrophage function observed.
我们实验室之前的报告表明，富含多不饱和脂肪酸（n-6）的饮食会引起免疫组织代谢的重要变化。在本研究中，对喂食富含多不饱和脂肪酸（UC）或饱和脂肪酸（SC）饮食6周的大鼠的巨噬细胞代谢和功能改变进行了检测。UC组大鼠腹腔细胞迁移和巨噬细胞吞噬作用降低。这些变化与巨噬细胞代谢的改变有关。UC组炎症巨噬细胞中的葡萄糖-6-磷酸脱氢酶（G-6-PDh）也增加。这些发现表明，磷酸戊糖途径不是控制吞噬作用的唯一代谢因子。富含多不饱和脂肪酸的饮食降低了谷氨酰胺酶活性。因此，这种氨基酸可能是观察到的巨噬细胞功能受损的可能代谢原因之一。
