Anderson Wendy G, Arnold Robert M, Angus Derek C, Bryce Cindy L
Department of Medicine, Division of Hospital Medicine and Palliative Care Program, University of California, San Francisco, San Francisco, CA 94143-0903, USA.
J Gen Intern Med. 2008 Nov;23(11):1871-6. doi: 10.1007/s11606-008-0770-2. Epub 2008 Sep 9.
Family members of patients in intensive care units (ICUs) are at risk for mental health morbidity both during and after a patient's ICU stay.
To determine prevalences of and factors associated with anxiety, depression, posttraumatic stress and complicated grief in family members of ICU patients.
Prospective, longitudinal cohort study.
Fifty family members of patients in ICUs at a large university hospital participated.
We used the Control Preferences Scale to determine participants' role preferences for surrogate decision-making. We used the Hospital Anxiety and Depression Scale, Impact of Event Scale, and Inventory of Complicated Grief to measure anxiety and depression (at enrollment, 1 month, 6 months), posttraumatic stress (6 months), and complicated grief (6 months).
We interviewed all 50 participants at enrollment, 39 (78%) at 1 month, and 34 (68%) at 6 months. At the three time points, anxiety was present in 42% (95% CI, 29-56%), 21% (95% CI, 10-35%), and 15% (95% CI, 6-29%) of participants. Depression was present in 16% (95% CI, 8-28%), 8% (95% CI, 2-19%), and 6% (95% CI, 1-18%). At 6 months, 35% (95% CI, 21-52%) of participants had posttraumatic stress. Of the 38% who were bereaved, 46% (95% CI, 22-71%) had complicated grief. Posttraumatic stress was not more common in bereaved than nonbereaved participants, and neither posttraumatic stress nor complicated grief was associated with decision-making role preference or with anxiety or depression during the patient's ICU stay.
Symptoms of anxiety and depression diminished over time, but both bereaved and nonbereaved participants had high rates of posttraumatic stress and complicated grief. Family members should be assessed for posttraumatic stress and complicated grief.
重症监护病房(ICU)患者的家庭成员在患者入住ICU期间及之后都有出现心理健康问题的风险。
确定ICU患者家庭成员中焦虑、抑郁、创伤后应激障碍和复杂悲伤情绪的患病率及相关因素。
前瞻性纵向队列研究。
一所大型大学医院ICU患者的50名家庭成员参与了研究。
我们使用控制偏好量表来确定参与者在替代决策中的角色偏好。我们使用医院焦虑抑郁量表、事件影响量表和复杂悲伤量表来测量焦虑和抑郁(在入组时、1个月、6个月)、创伤后应激障碍(6个月)和复杂悲伤情绪(6个月)。
我们在入组时对所有50名参与者进行了访谈,1个月时对39名(78%)进行了访谈,6个月时对34名(68%)进行了访谈。在这三个时间点,分别有42%(95%可信区间,29%-56%)、21%(95%可信区间,10%-35%)和15%(95%可信区间,6%-29%)的参与者存在焦虑情绪。抑郁情绪的比例分别为16%(95%可信区间,8%-28%)、8%(95%可信区间,2%-19%)和6%(95%可信区间,1%-18%)。在6个月时,35%(95%可信区间,21%-52%)的参与者患有创伤后应激障碍。在38%失去亲人的参与者中,46%(95%可信区间,22%-71%)有复杂悲伤情绪。创伤后应激障碍在失去亲人的参与者中并不比未失去亲人的参与者更常见,创伤后应激障碍和复杂悲伤情绪均与决策角色偏好或患者在ICU住院期间的焦虑或抑郁无关。
焦虑和抑郁症状随时间减轻,但失去亲人和未失去亲人的参与者创伤后应激障碍和复杂悲伤情绪的发生率都很高。应对家庭成员进行创伤后应激障碍和复杂悲伤情绪的评估。