用于减肥手术的大鼠胃束带模型。
Rat gastric banding model for bariatric surgery.
作者信息
Kanno Hitoshi, Kiyama Teruo, Fujita Itsuo, Kato Shunji, Yoshiyuki Toshiro, Tajiri Takashi
机构信息
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
出版信息
J Nippon Med Sch. 2008 Aug;75(4):202-6. doi: 10.1272/jnms.75.202.
BACKGROUND
Adjustable gastric banding is a surgical approach to weight reduction. In this study we created a gastric banding model in rats to better understand the mechanism of body weight loss.
METHODS
Male Sprague-Dawley rats weighing 260 to 280 g were subjected to gastric banding (band group) (n=8) or to a sham operation (control group) (n=8). Body weights were monitored for 14 days, and daily food and water intake and nitrogen balance were monitored for 7 days.
RESULTS
Two rats in the band group died of malnutrition due to gastric stomal stenosis and obstruction caused by the gastric banding. Body weight gain during the 14 days after the operation was less in the band group than in the control group (p<0.01). Food intake during the 7 days after the operation was significantly less in the band group than in the control group (p<0.01), and water intake during the 7 days after the operation was significantly less in the band group than in the control group (p<0.01). Cumulative nitrogen balance was significantly less in the band group than in the control group (p<0.01).
CONCLUSION
Gastric banding decreased the body weight gain of rats by decreasing the amount of food intake because of the creation of a small gastric pouch.
背景
可调节胃束带术是一种减肥的手术方法。在本研究中，我们在大鼠中建立了胃束带模型，以更好地理解体重减轻的机制。
方法
将体重260至280克的雄性Sprague-Dawley大鼠进行胃束带术（束带组）（n = 8）或假手术（对照组）（n = 8）。监测体重14天，并监测每日食物和水摄入量以及氮平衡7天。
结果
束带组中有两只大鼠因胃束带导致的胃吻合口狭窄和梗阻死于营养不良。术后14天内束带组的体重增加少于对照组（p<0.01）。术后7天内束带组的食物摄入量明显少于对照组（p<0.01），术后7天内束带组的水摄入量明显少于对照组（p<0.01）。束带组的累积氮平衡明显少于对照组（p<0.01）。
结论
胃束带术通过形成小胃囊减少食物摄入量，从而降低了大鼠的体重增加。
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