Department Surgery, Mount Sinai School of Medicine, 5 E 98th Street, New York, NY 10029, USA.
Obes Surg. 2010 Sep;20(9):1293-305. doi: 10.1007/s11695-010-0135-x.
Bariatric surgery is considered the most effective current treatment for morbid obesity. Since the first publication of an article by Kremen, Linner, and Nelson, many experiments have been performed using animal models. The initial experiments used only malabsorptive procedures like intestinal bypass which have largely been abandoned now. These experimental models have been used to assess feasibility and safety as well as to refine techniques particular to each procedure. We will discuss the surgical techniques and the postsurgical physiology of the four major current bariatric procedures (namely, Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, and biliopancreatic diversion). We have also reviewed the anatomy and physiology of animal models. We have reviewed the literature and presented it such that it would be a reference to an investigator interested in animal experiments in bariatric surgery. Experimental animal models are further divided into two categories: large mammals that include dogs, cats, rabbits, and pig and small mammals that include rats and mice.
减重手术被认为是目前治疗病态肥胖最有效的方法。自 Kremen、Linner 和 Nelson 首次发表一篇文章以来，已经使用动物模型进行了许多实验。最初的实验仅使用肠旁路等吸收不良程序，现在这些程序已基本被放弃。这些实验模型被用于评估可行性和安全性，以及改进每种手术的技术。我们将讨论当前四种主要减重手术（即 Roux-en-Y 胃旁路术、胃带术、袖状胃切除术和胆胰分流术）的手术技术和术后生理学。我们还回顾了动物模型的解剖学和生理学。我们查阅了文献，并将其呈现出来，以供对减重手术动物实验感兴趣的研究人员参考。实验动物模型进一步分为两大类：包括狗、猫、兔子和猪在内的大型哺乳动物，以及包括老鼠在内的小型哺乳动物。
