Cummings Colleen M, Fristad Mary A
Department of Psychology, The Ohio State University, Columbus, Ohio 43210-1250, USA.
Curr Opin Pediatr. 2008 Oct;20(5):560-5. doi: 10.1097/MOP.0b013e32830fe3d2.
Bipolar disorder (BPD) is increasingly diagnosed in youth in both outpatient and inpatient settings. Research on BPD in youth has also increased dramatically; this paper summarizes issues of clinical relevance in primary care, advancements in the last year, and areas in which more research is needed.
Key issues and new developments are summarized in the following areas such as epidemiology and relevance, assessment and differential diagnosis, patient and family decision support, shared decision making and triage, treatment, and monitoring and collaboration with mental health professionals. Recent practice guidelines have important implications for diagnosis and treatment.
Early-onset BPD appears to have a more severe course and more comorbidity than later life onset, as well as longer delays in treatment seeking. Affected children show differences in cognitive functioning and neuroanatomy compared with the general population. Assessment of BPD in children needs to be comprehensive and longitudinal, as diagnosis remains a debated topic. Medications are a primary part of treatment, but more double-blind, placebo-controlled trials are needed. Psychosocial adjunctive treatment is important. Children with a family history of BPD are at risk for impaired functioning and psychopathology; high-risk studies will increase our understanding of the onset and course of BPD.
双相情感障碍(BPD)在青少年门诊和住院患者中的诊断率日益增加。针对青少年双相情感障碍的研究也显著增多;本文总结了初级保健中具有临床相关性的问题、过去一年的进展以及仍需更多研究的领域。
以下领域总结了关键问题和新进展,如流行病学及相关性、评估与鉴别诊断、患者及家庭决策支持、共同决策与分诊、治疗以及与心理健康专业人员的监测与协作。近期的实践指南对诊断和治疗具有重要意义。
早发性双相情感障碍似乎比晚发性双相情感障碍病程更严重、合并症更多,且寻求治疗的延迟时间更长。与普通人群相比,受影响儿童在认知功能和神经解剖学方面存在差异。儿童双相情感障碍的评估需要全面且具有纵向性,因为诊断仍是一个有争议的话题。药物治疗是治疗的主要组成部分,但需要更多双盲、安慰剂对照试验。心理社会辅助治疗很重要。有双相情感障碍家族史的儿童存在功能受损和精神病理学风险;高风险研究将增进我们对双相情感障碍发病和病程的理解。