Holtmann Martin, Bölte Sven, Goth Kirstin, Döpfner Manfred, Plück Julia, Huss Michael, Fegert Jörg M, Lehmkuhl Gerd, Schmeck Klaus, Poustka Fritz
Department of Child and Adolescent Psychiatry and Psychotherapy, JW Goethe-University, Frankfurt/Main, Germany.
Bipolar Disord. 2007 Dec;9(8):895-900. doi: 10.1111/j.1399-5618.2007.00463.x.
In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date.
To estimate the six-month prevalence of the CBCL-PBD profile in Germany in a large normative general population sample, and to examine subjects with CBCL-PBD profile with regard to symptoms assumed to coexist with PBD (e.g., suicidality, decreased need for sleep, and hypersexuality).
We studied a nationwide representative general population sample of 2,856 children and adolescents aged 4-18 years.
A total of 21 subjects [0.7% of the sample; 95% confidence interval (CI) = 0.5-1.1] met the criteria for the CBCL-PBD phenotype. CBCL-PBD subjects were more pervasively disturbed than clinical controls (n = 118; 4.1% of total sample; 95% CI = 3.4-4.9), demonstrated in significantly more social problems and delinquent behavior, and showed significantly higher rates of suicidality, decreased need for sleep and hypersexual behavior.
The prevalence of CBCL-PBD subjects in the general German population compares to rates of PBD in US and Dutch epidemiological samples. Regardless of whether these subjects are affected by 'real' PBD or 'severe, pervasive ADHD' with pronounced emotional dysregulation, they constitute a group of seriously disturbed children and adolescents. The high rate of suicidality among CBCL-PBD subjects emphasizes the need for the identification and adequate treatment of children meeting this profile.
在患有儿童双相情感障碍（PBD）的儿童中，通过儿童行为清单（CBCL - PBD 剖面图）已确定了注意力不集中/多动、抑郁/焦虑和攻击行为增加的一致模式。在德国，迄今为止尚无包含 PBD 的流行病学研究。
在一个大型的正常普通人群样本中估计德国 CBCL - PBD 剖面图的六个月患病率，并检查具有 CBCL - PBD 剖面图的受试者是否存在被认为与 PBD 共存的症状（例如自杀倾向、睡眠需求减少和性欲亢进）。
我们研究了一个全国代表性的 2856 名 4 - 18 岁儿童和青少年的普通人群样本。
共有 21 名受试者[占样本的 0.7%；95%置信区间（CI）= 0.5 - 1.1]符合 CBCL - PBD 表型标准。CBCL - PBD 受试者比临床对照（n = 118；占总样本的 4.1%；95%CI = 3.4 - 4.9）受到的干扰更广泛，表现出更多的社会问题和违法行为，并且自杀倾向、睡眠需求减少和性行为亢进的发生率显著更高。
德国普通人群中 CBCL - PBD 受试者的患病率与美国和荷兰流行病学样本中的 PBD 患病率相当。无论这些受试者是受“真正的”PBD 影响，还是受伴有明显情绪失调的“严重、广泛性注意力缺陷多动障碍”影响，他们都构成了一组严重受扰的儿童和青少年。CBCL - PBD 受试者中自杀倾向的高发生率强调了识别和妥善治疗符合该剖面图的儿童的必要性。
