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无氧跳跃训练的糖尿病大鼠的中性粒细胞反应

Neutrophil response of anaerobic jump trained diabetic rats.

作者信息

de Souza Carine Ferreira, Machado Andressa Franzói, Bonatto Sandro José Ribeiro, Grando Fernanda Cristine Ceccon, Pessini Cristina, Alves Luciana Eberhardt, de Lima Carina, de Brito Gleisson Allison Pereira, Nunes Everson Araújo, Fernandes Luiz Cláudio

机构信息

Department of Physiology, Setor de Ciências Biológicas, Universidade Federal do Paraná, Biological Science Building, 81530-970 Curitiba, Paraná, Brazil.

出版信息

Eur J Appl Physiol. 2008 Dec;104(6):1079-86. doi: 10.1007/s00421-008-0865-9. Epub 2008 Sep 10.

Abstract

This paper investigated the effect of jump training on blood biochemical parameters and neutrophil responses of diabetic rats. Male Wistar rats were divided into control, trained, diabetic and trained-diabetic groups. Diabetes was induced by i.v. injection of streptozotocin. Jump training consisted of six sets of ten jumps in water with overload of 50% of body mass with 1-min of resting, four times per week during 6 weeks. Plasma glucose, lactate, triacylglycerol and total cholesterol concentrations, differential leukocyte count, phagocytosis and anion superoxide production by neutrophils were evaluated. Diabetes caused hyperglycemia, hypertriacylglycerolemia, and body weight loss. Physical training reversed hypertriacylglycerolemia. Jump training increased phagocytosis and anion superoxide production by blood neutrophils from trained and trained-diabetic rats. Neutrophilia and lymphocytopenia occur in diabetic and trained-diabetic rats. Anaerobic jump training in diabetic rats reduced hypertriacylglycerolemia and increased neutrophil anion superoxide production. Phagocytosis was not altered in trained-diabetic rats.

摘要

本文研究了跳跃训练对糖尿病大鼠血液生化参数及中性粒细胞反应的影响。雄性Wistar大鼠被分为对照组、训练组、糖尿病组和训练糖尿病组。通过静脉注射链脲佐菌素诱导糖尿病。跳跃训练包括在水中进行六组,每组十次跳跃,负荷为体重的50%,每次跳跃后休息1分钟,每周进行四次,共持续6周。评估了血浆葡萄糖、乳酸、三酰甘油和总胆固醇浓度、白细胞分类计数、中性粒细胞的吞噬作用和阴离子超氧化物生成。糖尿病导致高血糖、高三酰甘油血症和体重减轻。体育锻炼逆转了高三酰甘油血症。跳跃训练增加了训练组和训练糖尿病组大鼠血液中性粒细胞的吞噬作用和阴离子超氧化物生成。糖尿病组和训练糖尿病组大鼠出现中性粒细胞增多和淋巴细胞减少。糖尿病大鼠的无氧跳跃训练降低了高三酰甘油血症并增加了中性粒细胞阴离子超氧化物生成。训练糖尿病组大鼠的吞噬作用未改变。

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