Li Yi-Wei, Qiu Shuang-Jian, Fan Jia, Gao Qiang, Zhou Jian, Xiao Yong-Sheng, Xu Yang, Wang Xiao-Ying, Sun Jian, Huang Xiao-Wu
Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People's Republic of China.
J Cancer Res Clin Oncol. 2009 Mar;135(3):439-49. doi: 10.1007/s00432-008-0469-0. Epub 2008 Sep 10.
To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection.
The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.
High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040).
Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.
评估肿瘤相关巨噬细胞（TAM）单独或与CD45RO + 记忆T细胞（T(M)）协同作用对肝细胞癌（HCC）患者切除术后的预后价值。
通过免疫组织化学评估包含302例HCC标本的组织芯片中TAM和T(M)的浸润情况。对TAM/T(M)浸润与临床病理特征、无病生存期（DFS）和总生存期（OS）之间的相关性进行统计学分析。
高TAM浸润与改善的DFS（P = 0.0021）和OS（P = 0.0481）均相关。多因素分析确定TAM浸润是DFS（P = 0.004）和OS（P = 0.049）的独立预后因素。第二项分析明确了TAM和T(M)浸润对DFS（P = 0.004）和OS（P = 0.040）的协同作用。
单独的TAM浸润以及TAM和T(M)的伴随浸润均与改善的DFS/OS相关，提示TAM可通过不同机制保护HCC患者免于复发/转移并延长生存期。
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