Friedman R A, Shahin M, Zuckerbraun S
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
J Biomol Struct Dyn. 1991 Apr;8(5):977-88. doi: 10.1080/07391102.1991.10507861.
The 9-aminoacridine-DNA binding curve is analyzed in two ways: with polyelectrolyte effects neglected and with polyelectrolyte effects included. It is found that the analysis which includes polyelectrolyte effects is consistent with the violation of neighbor exclusion displayed by diacridine complexes as observed by Atwell et al. and by Zimmerman and coworkers. However the analysis which neglects polyelectrolyte effects is inconsistent with the diacridine results. This comparison supports the necessity of including polyelectrolyte effects in the analysis of drug-DNA binding curves.
9-氨基吖啶与DNA的结合曲线通过两种方式进行分析：一种是忽略聚电解质效应，另一种是考虑聚电解质效应。结果发现，考虑聚电解质效应的分析与阿特韦尔等人以及齐默尔曼及其同事所观察到的二吖啶复合物表现出的邻位排斥违反情况一致。然而，忽略聚电解质效应的分析与二吖啶的结果不一致。这种比较支持了在药物与DNA结合曲线分析中纳入聚电解质效应的必要性。
