用亚硒酸盐替代磷酸盐：对蛋白酪氨酸磷酸酶的不可逆抑制
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
作者信息
Abdo Mohannad, Liu Sijiu, Zhou Bo, Walls Chad D, Wu Li, Knapp Spencer, Zhang Zhong-Yin
机构信息
Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA.
出版信息
J Am Chem Soc. 2008 Oct 8;130(40):13196-7. doi: 10.1021/ja804489m. Epub 2008 Sep 10.
PMID:18781746
Abstract
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.
摘要
一种基于高酪氨酸的亚硒酸通过与活性位点半胱氨酸巯基特异性形成共价硒硫键，不可逆地抑制蛋白质酪氨酸磷酸酶。模型合成研究以及动力学、质谱和晶体学表征揭示了这一过程的详细信息。
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