2-苯氧基乙醇衍生的二硒化物及相关化合物；一种七元硒酸酯的合成。
2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester.
机构信息
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India.
出版信息
Org Biomol Chem. 2011 Jan 21;9(2):581-7. doi: 10.1039/c0ob00038h. Epub 2010 Nov 4.
PMID:21049128
Abstract
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good GPx-like activity in the coupled reductase assay.
摘要
描述了几种二有机二硒化物的合成，特别是衍生自 2-苯氧基乙醇的七元环状硒酸酯。该硒酸酯通过一系列氧化和 [2,3]σ重排步骤，从烯丙基(2-(2-羟乙氧基)苯基)硒化物中得到。该酯在偶联还原酶测定中表现出良好的 GPx 样活性。
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