Lu X, Lu D, Scully M F, Kakkar V V
Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK.
Curr Pharm Des. 2008;14(22):2140-58. doi: 10.2174/138161208785740199.
Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in atherosclerosis. This review considers the potential role of integrins in atherosclerosis and also addresses why integrins present attractive targets for drug design. It discusses the properties of the integrin-based chemotherapeutic agents currently under consideration clinically and endeavours to provide insights into development of cardiovascular drugs using integrins as targets.
据报道，整合素可介导细胞存活、增殖、分化和迁移程序。因此，在过去几年中，人们对整合素受体在动脉粥样硬化中的影响越来越感兴趣。本综述考虑了整合素在动脉粥样硬化中的潜在作用，并探讨了为何整合素成为药物设计的有吸引力的靶点。它讨论了目前正在临床研究中的基于整合素的化疗药物的特性，并努力为以整合素为靶点的心血管药物开发提供见解。
