白细胞介素1受体拮抗剂基因多态性并非复发性流产的危险因素：对夫妇的评估
Interleukin 1 receptor antagonist gene polymorphisms are not risk factors for recurrent pregnancy loss: evaluation of couples.
作者信息
Levrant Seth, Coulam Carolyn B, Jeyendran Rajasingam S
机构信息
Reproductive Health, Tinley Park, IL, USA.
出版信息
Am J Reprod Immunol. 2008 Sep;60(3):224-8. doi: 10.1111/j.1600-0897.2008.00617.x.
PROBLEM
The interleukin-1 system has been implicated in pregnancy outcome. Fetal carriage of interleukin-1 receptor antagonist (IL-1Ra) specific alleles has been associated with adverse pregnancy outcomes including spontaneous abortion and pre-term labor. This study was undertaken to compare the frequency of IL-1RN 2 alleles among both male and female partners of couples experiencing recurrent pregnancy loss with that of fertile control couples.
METHOD OF STUDY
Buccal swabs were obtained from 42 couples experiencing recurrent pregnancy loss and from 20 fertile control couples. DNA was extracted from the buccal swabs and analyzed for the presence of IL-1RN variable number tandem repeat.
RESULTS
No significant differences were found when the frequency of IL-1RN 2 polymorphisms were compared between fertile control couples and couples experiencing recurrent pregnancy loss. Similar results were also obtained when comparing women or men respectively from each group.
CONCLUSION
IL-1RN 2 allele is not a risk factor for recurrent pregnancy loss.
问题
白细胞介素 -1 系统与妊娠结局有关。胎儿携带白细胞介素 -1 受体拮抗剂（IL-1Ra）特定等位基因与不良妊娠结局相关，包括自然流产和早产。本研究旨在比较反复妊娠丢失夫妇的男性和女性伴侣中 IL-1RN 2 等位基因的频率与可育对照夫妇的频率。
研究方法
从 42 对反复妊娠丢失夫妇和 20 对可育对照夫妇中获取颊拭子。从颊拭子中提取 DNA，并分析 IL-1RN 可变数目串联重复序列的存在情况。
结果
比较可育对照夫妇和反复妊娠丢失夫妇的 IL-1RN 2 多态性频率时，未发现显著差异。分别比较每组中的女性或男性时，也获得了类似结果。
结论
IL-1RN 2 等位基因不是反复妊娠丢失的危险因素。
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