母体白细胞介素-1受体拮抗剂内含子2基因多态性与早产的关联。
Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.
作者信息
Murtha Amy P, Nieves Angel, Hauser Elizabeth R, Swamy Geeta K, Yonish Bryan A, Sinclair Tammy R, Heine R Phillips
机构信息
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, NC, USA.
出版信息
Am J Obstet Gynecol. 2006 Nov;195(5):1249-53. doi: 10.1016/j.ajog.2006.09.002.
OBJECTIVE
This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth.
STUDY DESIGN
A case-control study was performed. Cases (n = 95) delivered before 37 weeks after preterm labor (PTL) or preterm premature rupture of membranes (PPROM) and controls (n = 105) delivered after 37 weeks. Maternal DNA was genotyped by polymerase chain reaction for a length polymorphism in intron 2 of the IL-1RN gene.
RESULTS
There was no significant difference in maternal age, ethnicity, insurance status, or parity between groups. Allele and genotype frequencies did not differ significantly from that expected under Hardy-Weinberg equilibrium (P = .59) in the total group as well as study groups. Of the 95 cases, 26.8% had at least 1 copy of allele 2 present compared with 12.4% in the control group (P < .0004).
CONCLUSION
Maternal carriage of at least 1 copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth.
目的
本研究旨在确定白细胞介素-1受体拮抗剂（IL-1RN）可变数目串联重复多态性是否与早产相关。
研究设计
进行了一项病例对照研究。病例组（n = 95）为在早产（PTL）或胎膜早破（PPROM）后37周前分娩的产妇，对照组（n = 105）为在37周后分娩的产妇。通过聚合酶链反应对产妇DNA进行基因分型，以检测IL-1RN基因第2内含子的长度多态性。
结果
两组间产妇年龄、种族、保险状况或产次无显著差异。在总样本以及各研究组中，等位基因和基因型频率与哈迪-温伯格平衡预期值相比无显著差异（P = 0.59）。95例病例中，26.8%至少有1份等位基因2，而对照组为12.4%（P < 0.0004）。
结论
产妇携带至少1份IL-1RN等位基因2似乎与早产风险增加相关。
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