[基质金属蛋白酶-2、基质金属蛋白酶-9及IV型胶原在结直肠癌中的表达及其关系]
[Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas].
作者信息
Wu Wei, He Jian-tai, Ruan Jing-de, Wang Rong-bing, Zhang Yang-de
机构信息
Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Sep;24(9):908-9.
AIM
To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas.
METHODS
The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed.
RESULTS
The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9.
CONCLUSION
The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
目的
研究基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）及Ⅳ型胶原在结直肠癌中的表达及其相互关系。
方法
采用免疫组织化学染色法检测30例临床分期为Dukes'B期和C期患者的正常及结直肠癌组织中Ⅳ型胶原、MMP-2和MMP-9的表达，并分析Ⅳ型胶原、MMP-2和MMP-9之间的关系。
结果
结直肠癌组织中Ⅳ型胶原表达明显降低。正常结直肠组织未检测到MMP-2和MMP-9的表达，但在结直肠癌组织中其表达明显增加。Ⅳ型胶原与MMP-9的表达呈负相关。
结论
结直肠癌组织中Ⅳ型胶原的表达低于正常组织。MMP-9可能在结直肠癌中Ⅳ型胶原的降解过程中起重要作用。
Zotero 插件