选择性细胞毒性钌（II）芳烃茂金属阳离子配合物盐[R-PhRuCp*](+)X(-)，其中X = BF4(-)、PF6(-)和BPh4(-) 。
Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*](+)X(-) for X = BF4(-), PF6(-), and BPh4(-).
作者信息
Loughrey Bradley T, Healy Peter C, Parsons Peter G, Williams Michael L
机构信息
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia.
出版信息
Inorg Chem. 2008 Oct 6;47(19):8589-91. doi: 10.1021/ic801159f. Epub 2008 Sep 11.
PMID:18783214
Abstract
A novel series of ionic Ru(II) arene Cp* sandwich complexes has been synthesized and characterized. Screening results for cytotoxicity against a range of human tumor cell lines and normal human cells indicate that the complexes show promising anticancer activity, which varies with changes in the arene ligand and the anionic counterion.
摘要
已合成并表征了一系列新型离子型钌（II）芳烃五甲基环戊二烯夹心配合物。针对一系列人类肿瘤细胞系和正常人类细胞的细胞毒性筛选结果表明，这些配合物显示出有前景的抗癌活性，其活性随芳烃配体和阴离子抗衡离子的变化而变化。
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