Institut de Chimie, Université de Neuchâtel, Case postale 158, CH-2009 Neuchâtel, Switzerland.
Dalton Trans. 2010 Feb 21;39(7):1673-88. doi: 10.1039/b916860p. Epub 2009 Oct 23.
Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as hydrophobic properties due to the robustness of the ruthenium-arene unit hold a high potential for the development of metal-based anticancer drugs. Mononuclear arene ruthenium complexes containing P- or N-donor ligands or N,N-, N,O- or O,O-chelating ligands, dinuclear arene ruthenium systems with adjustable organic linkers, trinuclear arene ruthenium clusters containing an oxo cap, tetranuclear arene ruthenium porphyrin derivatives that are photoactive, as well as hexanuclear ruthenium cages that are either empty or filled with other molecules have been shown to be active against a variety of cancer cells.
中性或阳离子芳基钌配合物由于钌-芳基单元的坚固性而具有提供亲水性和疏水性的双重特性，因此具有开发基于金属的抗癌药物的巨大潜力。单核芳基钌配合物含有 P 或 N-供体配体或 N,N-、N,O-或 O,O-螯合配体，具有可调节有机连接体的双核芳基钌体系，含有氧帽的三核芳基钌簇，四核芳基钌卟啉衍生物具有光活性，以及空的或填充有其他分子的六核钌笼已被证明对多种癌细胞具有活性。
