Impens A J, Wangkaew S, Seibold J R
University of Michigan Scleroderma Program, 3918 Taubman Center/0358, Ann Arbor, MI 48109-0358, USA.
Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v68-9. doi: 10.1093/rheumatology/ken273.
The 6-min walk test (6MWT) is a standardized measure of submaximal exercise capacity that has served as the primary measure of outcome in studies of pulmonary arterial hypertension. Never fully validated in scleroderma, a variety of data suggest that many non-pulmonary aspects of scleroderma contribute to its results thereby blunting the ability of the 6MWT to measure change in lung function. Although reproducible, the lack of correlation with measures of parenchymal lung disease demonstrates an insurmountable lack of both construct and content validity. The 6MWT should be abandoned as an outcome measure in lung disease complicating scleroderma.
6分钟步行试验（6MWT）是一种次极量运动能力的标准化测量方法，已作为肺动脉高压研究的主要结局指标。6MWT在硬皮病中从未得到充分验证，各种数据表明，硬皮病的许多非肺部方面会影响其结果，从而削弱了6MWT测量肺功能变化的能力。尽管该试验具有可重复性，但与实质性肺部疾病测量指标缺乏相关性，表明其在结构效度和内容效度方面都存在无法克服的缺陷。在硬皮病合并肺部疾病中，6MWT作为结局指标应被摒弃。
