Delaere L, Zeyen T, Foets B, Van Calster J, Stalmans I
Department of Ophthalmology, University Hospitals Leuven, Campus St Raphaël, Kapucijnenvoer 33, 3000, Leuven, Belgium.
Int Ophthalmol. 2009 Dec;29(6):521-8. doi: 10.1007/s10792-008-9258-7. Epub 2008 Sep 11.
The enzyme hyaluronidase (HA) is an adjunctive in retrobulbar anaesthesia (RA) that is used during ophthalmic surgery to improve the efficacy and speed of nerve blocks. Although uncommon, HA has been shown to be a potential cause of allergic responses.
We describe three patients who experienced an allergic reaction to HA following ocular surgery in our department and provide an extensive overview of the literature on HA in RA.
Although rare and mostly benign, allergy to HA should be included in the differential diagnosis when chemosis, proptosis and restriction of eye movements occur after parabulbar or retrobulbar anaesthesia. The authors feel that the beneficial effect of HA in small volumes of RA warrants its use despite this potential complication.
透明质酸酶（HA）是球后麻醉（RA）中的一种辅助剂，在眼科手术中用于提高神经阻滞的效果和速度。尽管不常见，但HA已被证明是过敏反应的一个潜在原因。
我们描述了三名在我院眼科手术后对HA发生过敏反应的患者，并对关于RA中HA的文献进行了全面综述。
尽管罕见且大多为良性，但当球周或球后麻醉后出现球结膜水肿、眼球突出和眼球运动受限等情况时，HA过敏应纳入鉴别诊断。作者认为，尽管存在这种潜在并发症，但小剂量HA在RA中的有益作用仍值得使用。
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