Murray Gillian, Convery Cormac, Walker Lee, Davies Emma
Ms. Murray is with Clinical Academic Kings College in London, England.
Dr. Convery is with The Ever Clinic in Glasgow, Scotland.
J Clin Aesthet Dermatol. 2021 Aug;14(8):E69-E75. Epub 2021 Aug 1.
Vascular occlusions can occur with injection of dermal fillers, causing devastating outcomes for the patient. Hyaluronidase is an enzyme that was first used in general medicine in 1949, but has gained widespread use in aesthetic medicine to dissolve hyaluronic acid (HA)-based dermal fillers. Knowledge of this drug and its use for other aesthetic indications is evolving, and there is often anxiety attached to the administration of animal-derived product due to fears of an allergic reaction. This paper provides guidance on the indications for use when dissolving HA filler with hyaluronidase. It discusses formulation differences, adverse events, allergy to wasp and bee stings, and how this increases risk of allergy to hyaluronidase. It also discusses incidence of allergy, which includes a discussion of types of allergic response and how this correlates to skin tests and a discussion on skin testing for allergy.
注射真皮填充剂时可能会发生血管阻塞，给患者带来灾难性后果。透明质酸酶是一种酶，于1949年首次用于普通医学，但在美容医学中已广泛用于溶解基于透明质酸（HA）的真皮填充剂。关于这种药物及其在其他美容适应症中的应用的知识正在不断发展，并且由于担心过敏反应，使用动物源性产品时常常会引起焦虑。本文提供了关于使用透明质酸酶溶解HA填充剂的适应症指南。它讨论了制剂差异、不良事件、对黄蜂和蜜蜂叮咬的过敏以及这如何增加对透明质酸酶过敏的风险。它还讨论了过敏的发生率，包括对过敏反应类型的讨论以及这与皮肤试验的相关性，以及关于过敏皮肤试验的讨论。
