与白内障手术中使用透明质酸酶相关的血管性水肿。
Angioedema related to the use of hyaluronidase in cataract surgery.
作者信息
Eberhart Anne H, Weiler Catherine R, Erie Jay C
机构信息
Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
Am J Ophthalmol. 2004 Jul;138(1):142-3. doi: 10.1016/j.ajo.2004.02.035.
PURPOSE
To report a series of cases of angioedema related to the use of hyaluronidase in cataract surgery.
DESIGN
Observational case series.
METHODS
Three eyes of three patients who had periorbital angioedema after phacoemulsification at the Mayo Clinic, Rochester, Minnesota, between April 2001 and May 2002 were retrospectively skin tested for allergies using the prick technique.
RESULTS
Skin testing was positive in all three patients for allergy to hyaluronidase (150 U/cc) and histamine control; and negative for prick control, 2% lidocaine, 1% cyclopentolate, 2.5% neosynephrine, 0.5% proparacaine, 0.3% ofloxacin, and thimerosal.
CONCLUSIONS
The use of hyaluronidase in ophthalmic anesthesia injection may cause immediate type hypersensitivity reactions such as angioedema.
目的
报告一系列与白内障手术中使用透明质酸酶相关的血管性水肿病例。
设计
观察性病例系列。
方法
回顾性地对2001年4月至2002年5月在明尼苏达州罗切斯特市梅奥诊所接受超声乳化白内障吸除术后出现眶周血管性水肿的3例患者的3只眼，采用点刺技术进行皮肤过敏试验。
结果
所有3例患者对透明质酸酶（150 U/cc）和组胺对照的皮肤试验均呈阳性；对阴性对照、2%利多卡因、1%环喷托酯、2.5%去氧肾上腺素、0.5%丙美卡因、0.3%氧氟沙星和硫柳汞的皮肤试验均呈阴性。
结论
在眼科麻醉注射中使用透明质酸酶可能会引起速发型超敏反应，如血管性水肿。
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